891002-11-2

891002-11-2 structure

Name: SIRT6-IN-5
Chemical Name: 5-{[4-(2-Furoylamino)benzoyl]amino}-2-hydroxybenzoic acid
CAS Number: 891002-11-2
Molecular Formula: C₁₉H₁₄N₂O₆
Molecular Weight: 366.32
Catalog: Signaling Pathways Cell Cycle/DNA Damage Sirtuin
Create Date: 2021-09-10 18:24:33
Modify Date: 2024-02-04 08:55:55
SIRT6-IN-2 (Compound 5) is a selective SIRT6 inhibitor (IC50: 34 μM). SIRT6-IN-2 increases acetylation of H3K9 and increases glucose uptake in cultured cells. SIRT6-IN-2 also reduces T cell proliferation. SIRT6-IN-2 has immunosuppressive and chemosensitizing effects[1].

Name	5-{[4-(2-Furoylamino)benzoyl]amino}-2-hydroxybenzoic acid
Synonyms	5-{[4-(2-Furoylamino)benzoyl]amino}-2-hydroxybenzoic acid MFCD07114223 Benzoic acid, 5-[[4-[(2-furanylcarbonyl)amino]benzoyl]amino]-2-hydroxy-

Description	SIRT6-IN-2 (Compound 5) is a selective SIRT6 inhibitor (IC50: 34 μM). SIRT6-IN-2 increases acetylation of H3K9 and increases glucose uptake in cultured cells. SIRT6-IN-2 also reduces T cell proliferation. SIRT6-IN-2 has immunosuppressive and chemosensitizing effects[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Sirtuin Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin
Target	SIRT6[1]
References	[1]. Damonte P, et al. SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects. Bioorg Med Chem. 2017 Oct 15;25(20):5849-5858.