2566522-50-5

2566522-50-5 structure

Name: Antifungal agent 25
Chemical Name: Antifungal agent 25
CAS Number: 2566522-50-5
Molecular Formula: C₂₀H₁₄ClFN₄OS
Molecular Weight: 412.87
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2022-06-30 17:34:28
Modify Date: 2024-01-28 17:38:22
Antifungal agent 25 is a potent broad-spectrum antifungal agent. Antifungal agent 25 shows antifungal effect against Candida albicans and fluconazole-resistant strain of Candida albicans. Antifungal agent 25 stable metabolic property in vivo[1].

Name	Antifungal agent 25

Description	Antifungal agent 25 is a potent broad-spectrum antifungal agent. Antifungal agent 25 shows antifungal effect against Candida albicans and fluconazole-resistant strain of Candida albicans. Antifungal agent 25 stable metabolic property in vivo[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
In Vitro	Antifungal agent 25 (compound A31) shows antifungal effect with MIC values of <0.03, <0.03, <0.03, 0.25, 0.5 µg/mL for Candida albicans (SC5314), Candida albicans ((GIM 2.194), Cryptococcus neoformans (GIM 2.209), Candida tropicalis (GIM 2.183), Aspergillus fumigatus (cgmcc 3.7795), respectively[1]. Antifungal agent 25 shows moderate antifungal activity with MIC values of 0.5, >64 µg/mL for strain CaR (fluconazole-resistant strain of Candida albicans) and strain 17# (fluconazole and itraconazole resistant strain of Candida albicans), respectively[1]. Antifungal agent 25 (0.015 mg/mL) blocks the biosynthesis of ergosterol by inhibiting the key enzyme lanosterol 14a-demethylase (CYP51)[1]. Antifungal agent 25 shows less likely to produce drug-drug interactions with IC50s of 4.47, 2.87, 1.04, 31.3, 10.1 µM for α-naphthoflavone (CYP1A2), sulfaphenazole (CYP2C9), ticlopidine (CYP2C19), quinidine (CYP2D6), and ketoconazole (CYP3A4), respectively[1].
In Vivo	Antifungal agent 25 (2 mg/kg; i.v.) exhibits stable metabolic property in SD rats[1]. Pharmacokinetic Parameters of Antifungal agent 25 in SD rats[1]. dose(mg/kg) C0(ng/mL) T1/2(h) Vdss(L/kg) Cl (mL/min/kg) AUC0-last (ng·h/mL) AUC0-inf (ng·h/mL) 2 mg/kg 482±108 3.34±2.37 10.3±3.12 69.4±18.8 483±137 5.5±136SD rats; 2 mg/kg; i.v.[1]. Animal Model: SD rats[1] Dosage: 2 mg/kg Administration: I.v. Result: Exhibited stable metabolic property in SD rats.
References	[1]. Zhao L, et al. Design, synthesis, and biological activity evaluation of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives as broad-spectrum antifungal agents. Eur J Med Chem. 2022; 228:113987.

Molecular Formula	C₂₀H₁₄ClFN₄OS
Molecular Weight	412.87

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