2379527-72-5

2379527-72-5 structure

Name: IDO1/TDO-IN-1
Chemical Name: IDO1/TDO-IN-1
CAS Number: 2379527-72-5
Molecular Formula: C₂₁H₁₆O₆
Molecular Weight: 364.35
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-05-21 11:45:00
Modify Date: 2024-01-10 00:26:30
IDO1/TDO-IN-1 (30) is a potent dual IDO1 (uncompetitive, Ki of 0.23 μM) and TDO (competitive, Ki of 0.73 μM) inhibitor. IDO1/TDO-IN-1 (30) significantly promotes cell apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway[1].

Name	IDO1/TDO-IN-1

Description	IDO1/TDO-IN-1 (30) is a potent dual IDO1 (uncompetitive, Ki of 0.23 μM) and TDO (competitive, Ki of 0.73 μM) inhibitor. IDO1/TDO-IN-1 (30) significantly promotes cell apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO)
Target	IDO1:0.23 μM (Ki) TDO:0.73 μM (Ki)
References	[1]. Jiangxin Liu, et al. Discovery and biological evaluation of tanshinone derivatives as potent dual inhibitors of indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase. Eur J Med Chem. 2022 May 5;235:114294.

Molecular Formula	C₂₁H₁₆O₆
Molecular Weight	364.35