2033173-01-0

2033173-01-0 structure

Name: IDO/TDO-IN-1
Chemical Name: IDO/TDO-IN-1
CAS Number: 2033173-01-0
Molecular Formula: C₂₅H₂₄FN₅
Molecular Weight: 413.49
Catalog: Signaling Pathways Metabolic Enzyme/Protease Indoleamine 2,3-Dioxygenase (IDO)
Create Date: 2019-08-04 13:37:59
Modify Date: 2024-01-03 15:13:36
IDO/TDO-IN-1 (compound 25) is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50s of 9.7 and 47 nM, respectively [1].

Name	IDO/TDO-IN-1

Description	IDO/TDO-IN-1 (compound 25) is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50s of 9.7 and 47 nM, respectively [1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO)
Target	IC50: 9.7 nM (Indoleamine-2,3-dioxygenase), 47 nM (Tryptophan 2,3-dioxygenase)[1]
In Vitro	IDO/TDO-IN-1 inhibits IDO in the Hela cell line with an IC50 of 76 nM[1].
References	[1]. Tu W, et al. Discovery of Imidazoisoindole Derivatives as Highly Potent and Orally Active Indoleamine-2,3-dioxygenase Inhibitors. ACS Med Chem Lett. 2019 Jun 3;10(6):949-953.

Molecular Formula	C₂₅H₂₄FN₅
Molecular Weight	413.49