2493978-38-2
2493978-38-2 structure
- Name: TIM-063
- Chemical Name: TIM-063
- CAS Number: 2493978-38-2
- Molecular Formula: C18H9N3O4
- Molecular Weight: 331.287
- Catalog: Signaling Pathways Neuronal Signaling CaMK
- Create Date: 2022-07-10 20:10:57
- Modify Date: 2024-01-08 18:25:33
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TIM-063 (TIM063) is a potent, selective, ATP-competitive CaMKK inhibitor with Ki of 0.35/0.2 uM for CaMKKα and CaMKKβ, respectively.TIM-063 directly targets the catalytic domain of CaMKK, similar to STO-609.TIM-063 suppressed the ionomycin-induced phosphorylation of exogenously expressed CaMKI, CaMKIV, and endogenous AMPKα in HeLa cells with an IC50 of 0.3 uM.TIM-063 suppressed CaMKK isoform-mediated CaMKIV phosphorylation in transfected COS-7 cells.TIM-063 displayed cell permeability and the ability to inhibit CaMKK activity in cells. TIM-063 is a useful chemical probe for the precise analysis of CaMKK-mediated signaling pathways.
| Name | TIM-063 |
|---|
| Description | TIM-063 (TIM063) is a potent, selective, ATP-competitive CaMKK inhibitor with Ki of 0.35/0.2 uM for CaMKKα and CaMKKβ, respectively.TIM-063 directly targets the catalytic domain of CaMKK, similar to STO-609.TIM-063 suppressed the ionomycin-induced phosphorylation of exogenously expressed CaMKI, CaMKIV, and endogenous AMPKα in HeLa cells with an IC50 of 0.3 uM.TIM-063 suppressed CaMKK isoform-mediated CaMKIV phosphorylation in transfected COS-7 cells.TIM-063 displayed cell permeability and the ability to inhibit CaMKK activity in cells. TIM-063 is a useful chemical probe for the precise analysis of CaMKK-mediated signaling pathways. |
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| References | 1. Ohtsuka S, et al. Biochemistry. 2020 May 5;59(17):1701-1710. 2. Satomi Ohtsuka, et al. Biochemistry, March 11, 2022. 3. Toshio Kitazawa, et al. Am J Physiol Cell Physiol. 2021 Sep 1;321(3):C549-C558. |
| Molecular Formula | C18H9N3O4 |
|---|---|
| Molecular Weight | 331.287 |