Shanghai Nianxing Industrial Co., Ltd
China
Product Name: ABBV-318
Price:
Purity: 99.61%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: ABBV-318
Price: ￥1470.0/100mg
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tony Cao

1802848-94-7

1802848-94-7 structure

1802848-94-7 structure

Name: ABBV-318
Chemical Name: ABBV-318
CAS Number: 1802848-94-7
Molecular Formula: C₂₀H₁₅F₄N₃O₂
Molecular Weight: 405.35
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Sodium Channel
Create Date: 2022-07-02 15:50:16
Modify Date: 2024-01-10 22:42:01
ABBV-318 is a potent Nav1.7/ Nav1.8 blocker, with IC50s of 2.8 μM and 3.8 μM for hNav1.7 and hNav1.8, respectively. ABBV-318 can be used for the research of pain[1].

Name	ABBV-318

Description	ABBV-318 is a potent Nav1.7/ Nav1.8 blocker, with IC50s of 2.8 μM and 3.8 μM for hNav1.7 and hNav1.8, respectively. ABBV-318 can be used for the research of pain[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease
Target	hNav1.7:2.8 μM (IC50) hNav1.8:3.3 μM (IC50)
References	[1]. Patel MV, et, al. Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Na v 1.7/ Nav1.8 blockers for the treatment of pain. Bioorg Med Chem. 2022 Jun 1;63:116743.

Molecular Formula	C₂₀H₁₅F₄N₃O₂
Molecular Weight	405.35