1809266-03-2
1809266-03-2 structure
- Name: ABBV-4083
- Chemical Name: ABBV-4083
- CAS Number: 1809266-03-2
- Molecular Formula: C53H82FNO17
- Molecular Weight: 1024.21
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2019-06-02 09:45:56
- Modify Date: 2024-01-10 12:06:30
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ABBV-4083 is an analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity[1].
| Name | ABBV-4083 |
|---|
| Description | ABBV-4083 is an analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity[1]. |
|---|---|
| Related Catalog | |
| In Vivo | ABBV-4083 (150 mg/kg, once daily for 14 days) reduces Wolbachia levels (measured 16 weeks post-treatment-initiation, pti) in mice by >99.9% in the recovered female adult worms. Levels of circulating microfilariae declines from ~7 weeks pti and are completely cleared from 12 weeks pti until the end of this study at 16 weeks pti[1]. Animal Model: Female BALB/c mice or female jirds were infected at 6–8 weeks of age with L. sigmodontis larvae through the bites of Ornithonyssus bacoti mites[1]. Dosage: 150 mg/kg. Administration: PO once daily for 14 days started at 14 weeks post infection (pti). Result: Wolbachia levels (measured 16 weeks post-treatment-initiation, pti) were reducedby >99.9% in the recovered female adult worms. Starting at ~7 weeks pti, levels of circulating microfilariae declined and were completely cleared from 12 weeks pti until the end of this study at 16 weeks pti. |
| References |
| Molecular Formula | C53H82FNO17 |
|---|---|
| Molecular Weight | 1024.21 |