2226229-76-9

2226229-76-9 structure

2226229-76-9 structure

Name: ATG7-IN-3
Chemical Name: ATG7-IN-3
CAS Number: 2226229-76-9
Molecular Formula: C₁₁H₁₆N₆O₅S₂
Molecular Weight: 376.41
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2022-07-01 06:09:36
Modify Date: 2024-01-14 11:47:00
ATG7-IN-3 (compound 18) is a potent ATG7 inhibitor, with an IC50 of 0.048 μM. ATG7-IN-3 inhibits autophagy. ATG7-IN-3 inhibits the formation of endogenous LC3B puncta in the neuroglioma cell line H4[1].

Name	ATG7-IN-3

Description	ATG7-IN-3 (compound 18) is a potent ATG7 inhibitor, with an IC50 of 0.048 μM. ATG7-IN-3 inhibits autophagy. ATG7-IN-3 inhibits the formation of endogenous LC3B puncta in the neuroglioma cell line H4[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy
Target	IC50: 0.048 ± 0.022 μM (ATG7), 0.280 ± 0.051 μM (Thioester), 0.938 ± 0.231 μM (LC3B)[1]
References	[1]. Huang SC, et al. Discovery and optimization of pyrazolopyrimidine sulfamates as ATG7 inhibitors. Bioorg Med Chem. 2020 Oct 1;28(19):115681.

Molecular Formula	C₁₁H₁₆N₆O₅S₂
Molecular Weight	376.41