2756665-52-6

2756665-52-6 structure

Name: ATR-IN-15
Chemical Name: ATR-IN-15
CAS Number: 2756665-52-6
Molecular Formula: C₁₉H₂₂N₈O
Molecular Weight: 378.43
Catalog: Signaling Pathways Cell Cycle/DNA Damage ATM/ATR
Create Date: 2022-06-26 13:28:12
Modify Date: 2024-01-10 12:08:12
ATR-IN-15 (compound 1) is an orally active and potent ATR kinase inhibitor, with an IC50 of 8 nM. ATR-IN-15 also inhibits human colon tumor cells LoVo, DNA-PK and PI3K, with IC50 values of 47, 663 and 5131 nM, respectively[1].

Name	ATR-IN-15

Description	ATR-IN-15 (compound 1) is an orally active and potent ATR kinase inhibitor, with an IC50 of 8 nM. ATR-IN-15 also inhibits human colon tumor cells LoVo, DNA-PK and PI3K, with IC50 values of 47, 663 and 5131 nM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> ATM/ATR Signaling Pathways >> Cell Cycle/DNA Damage >> DNA-PK Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Signaling Pathways >> PI3K/Akt/mTOR >> ATM/ATR Signaling Pathways >> PI3K/Akt/mTOR >> DNA-PK
Target	ATR:8 nM (IC50) PI3K:5131 nM (IC50) ATM:> 10000 nM (IC50)
References	[1]. Xin Li, et al. Imidazopyrimidine derivative, preparation method therefor and medical use thereof. WO2022002243A1.

Molecular Formula	C₁₉H₂₂N₈O
Molecular Weight	378.43