2488943-55-9

2488943-55-9 structure

Name: CXCR4 modulator-2
Chemical Name: CXCR4 modulator-2
CAS Number: 2488943-55-9
Molecular Formula: C₂₁H₃₂N₈O₂
Molecular Weight: 428.53
Catalog: Signaling Pathways GPCR/G Protein CXCR
Create Date: 2022-07-07 19:01:43
Modify Date: 2024-01-16 17:15:05
CXCR4 modulator-2 (compound Z7R) is a highly potent CXCR4 modulator with an IC50 value of 1.25 nM. CXCR4 modulator-2 has acceptable stability (t1/2 = 77.1 min) in mouse serum and exhibits anti-inflammatory activity in mouse edema model[1].

Name	CXCR4 modulator-2

Description	CXCR4 modulator-2 (compound Z7R) is a highly potent CXCR4 modulator with an IC50 value of 1.25 nM. CXCR4 modulator-2 has acceptable stability (t1/2 = 77.1 min) in mouse serum and exhibits anti-inflammatory activity in mouse edema model[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CXCR Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> CXCR
Target	CXCR4:1.25 nM (IC50)
In Vivo	CXCR4 modulator-2 (10 mg/kg; IP; single dosage) significantly reduces the edema weights (∼50%) in the lesion and decreases the expression of CXCR4s[1]. Animal Model: male nude mice (6 weeks, 20 g; subcutaneous injection of 50 μL of λ-carrageenan)[1] Dosage: 10 mg/kg Administration: IP; single dosage Result: Significantly reduced the edema weights (∼50%) in the lesion and decreased the expression of CXCR4s.
References	[1]. Oum YH, et al. Discovery of novel aminopiperidinyl amide CXCR4 modulators through virtual screening and rational drug design. Eur J Med Chem. 2020;201:112479.

Molecular Formula	C₂₁H₃₂N₈O₂
Molecular Weight	428.53