2554622-28-3

2554622-28-3 structure

Name: HIV-1 inhibitor-23
Chemical Name: HIV-1 inhibitor-23
CAS Number: 2554622-28-3
Molecular Formula: C₃₀H₂₆N₆O₄S
Molecular Weight: 566.63
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2022-07-01 11:09:03
Modify Date: 2024-01-23 16:44:04
HIV-1 inhibitor-23 (compound 12a) is a highly potent HIV-1 non-nucleoside reverse transcriptase inhibitor, with EC50s of 24.9 nM and 10.4 nM for HIV-1 WT and HIV-1 K103N, respectively. HIV-1 inhibitor-23 has low cytotoxicity (CC50 > 221 μM) and a favorable in vitro microsomal stability[1].

Name	HIV-1 inhibitor-23

Description	HIV-1 inhibitor-23 (compound 12a) is a highly potent HIV-1 non-nucleoside reverse transcriptase inhibitor, with EC50s of 24.9 nM and 10.4 nM for HIV-1 WT and HIV-1 K103N, respectively. HIV-1 inhibitor-23 has low cytotoxicity (CC50 > 221 μM) and a favorable in vitro microsomal stability[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HIV-1 (WT):24.9 nM (EC50) HIV-1 (K103N):10.4 nM (EC50)
References	[1]. Han S, et al. Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors. Eur J Med Chem. 2020;185:111874.

Molecular Formula	C₃₀H₂₆N₆O₄S
Molecular Weight	566.63