2230873-67-1
2230873-67-1 structure
- Name: KRAS inhibitor-16
- Chemical Name: KRAS inhibitor-16
- CAS Number: 2230873-67-1
- Molecular Formula: C20H16Cl2FN3O2S
- Molecular Weight: 452.33
- Catalog: Signaling Pathways GPCR/G Protein Ras
- Create Date: 2022-07-02 18:15:31
- Modify Date: 2024-01-06 20:20:30
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KRAS inhibitor-16 (compound 3-11) is a potent KRAS G12C inhibitor with an IC50 of 0.457 µM. KRAS inhibitor-16 shows p-ERK inhibition activities with IC50s of 3.06, 11.1 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-16 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
| Name | KRAS inhibitor-16 |
|---|
| Description | KRAS inhibitor-16 (compound 3-11) is a potent KRAS G12C inhibitor with an IC50 of 0.457 µM. KRAS inhibitor-16 shows p-ERK inhibition activities with IC50s of 3.06, 11.1 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-16 has the potential for the research of pancreatic, colorectal, and lung cancers[1]. |
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| Related Catalog | |
| Target |
KRas G12C:0.457 μM (IC50) |
| References |
[1]. Brian Alan LANMAN, et al. Kras g12c inhibitors and methods of using the same. US20180334454A1. |
| Molecular Formula | C20H16Cl2FN3O2S |
|---|---|
| Molecular Weight | 452.33 |