1443242-46-3

1443242-46-3 structure
1443242-46-3 structure
  • Name: p38-α MAPK-IN-5
  • Chemical Name: p38-α MAPK-IN-5
  • CAS Number: 1443242-46-3
  • Molecular Formula: C37H49N11O2
  • Molecular Weight: 679.86
  • Catalog: Signaling Pathways MAPK/ERK Pathway p38 MAPK
  • Create Date: 2022-08-06 01:28:27
  • Modify Date: 2024-01-10 09:47:42
  • p38-α MAPK-IN-5 (compound 4e) is a potent p38α inhibitor with IC50s of 0.1 nM, 0.2 nM, 944 nM, 4100 nM for p38α, p38 β, p38γ, p38δ, respectively. p38-α MAPK-IN-5 has anti-inflammatory effect. p38-α MAPK-IN-5 has the potential for asthma and chronic obstructive pulmonary disease (COPD) research[1].

Name p38-α MAPK-IN-5
Description p38-α MAPK-IN-5 (compound 4e) is a potent p38α inhibitor with IC50s of 0.1 nM, 0.2 nM, 944 nM, 4100 nM for p38α, p38 β, p38γ, p38δ, respectively. p38-α MAPK-IN-5 has anti-inflammatory effect. p38-α MAPK-IN-5 has the potential for asthma and chronic obstructive pulmonary disease (COPD) research[1].
Related Catalog
Target

p38α:0.1 nM (IC50)

p38β:0.2 nM (IC50)

p38γ:944 nM (IC50)

p38δ:4100 nM (IC50)

References

[1]. Elisabetta Armani, et al. Design, Synthesis, and Biological Characterization of Inhaled p38α/β MAPK Inhibitors for the Treatment of Lung Inflammatory Diseases. J Med Chem. 2022 May 26;65(10):7170-7192.

Molecular Formula C37H49N11O2
Molecular Weight 679.86