2485732-30-5

2485732-30-5 structure

2485732-30-5 structure

Name: PAK1-IN-1
Chemical Name: PAK1-IN-1
CAS Number: 2485732-30-5
Molecular Formula: C₂₆H₂₀ClN₅O₂
Molecular Weight: 469.92
Catalog: Signaling Pathways Cell Cycle/DNA Damage PAK
Create Date: 2022-07-01 17:58:04
Modify Date: 2024-01-14 15:25:35
PAK1-IN-1 is a potent and selective PAK1 inhibitor with an IC50 of 9.8 nM. PAK1-IN-1 inhibits the migration and invasion of PAK1-related tumour cells in a dose-dependent manner[1].

Name	PAK1-IN-1

Description	PAK1-IN-1 is a potent and selective PAK1 inhibitor with an IC50 of 9.8 nM. PAK1-IN-1 inhibits the migration and invasion of PAK1-related tumour cells in a dose-dependent manner[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cytoskeleton >> PAK Signaling Pathways >> Cell Cycle/DNA Damage >> PAK
Target	PAK1:9.8 nM (IC50) PAK4:>10 μM (IC50)
In Vitro	PAK1-IN-1 (compound 30l) (0-10 µM) shows selectivity with IC50s of 0.01, >10 µM for PAK1 and PAK4, respectively[1]. Cell Proliferation Assay[1] Cell Line: MDA-MB-231, HCT-116 cells Concentration: 1 µM Incubation Time: 72 h Result: Showed antiproliferative activity against MDA-MB-231and HCT-116 cells with inhibition of 6.31% and 8.73%, respectively. Western Blot Analysis[1] Cell Line: MDA-MB-231 cells Concentration: 2.5, 5, 10, 20 µM Incubation Time: 1, 24 h Result: Decreased the expression of activated PAK1 (PAKp-Ser144) and Snail in a dose-dependent manner.
References	[1]. Zhang M, et al. Design and synthesis of 1H-indazole-3-carboxamide derivatives as potent and selective PAK1 inhibitors with anti-tumour migration and invasion activities. Eur J Med Chem. 2020 Oct 1;203:112517.

Molecular Formula	C₂₆H₂₀ClN₅O₂
Molecular Weight	469.92