2408639-81-4

2408639-81-4 structure

Name: Topoisomerase I inhibitor 7
Chemical Name: Topoisomerase I inhibitor 7
CAS Number: 2408639-81-4
Molecular Formula: C₂₂H₁₉N₃O₅
Molecular Weight: 405.40
Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
Create Date: 2022-06-27 10:37:28
Modify Date: 2024-01-10 15:11:14
Topoisomerase I inhibitor 7 (Compound 8) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 7 significantly inhibits tumor growth (up to 79%) and increases the lifespan (153%) of mice bearing P388 lymphoma transplants. Topoisomerase I inhibitor 7 indicates prospects for further search of new antitumor drug candidates among the heteroarene-fused anthraquinones[1].

Name	Topoisomerase I inhibitor 7

Description	Topoisomerase I inhibitor 7 (Compound 8) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 7 significantly inhibits tumor growth (up to 79%) and increases the lifespan (153%) of mice bearing P388 lymphoma transplants. Topoisomerase I inhibitor 7 indicates prospects for further search of new antitumor drug candidates among the heteroarene-fused anthraquinones[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
References	[1]. Tikhomirov AS, et al. Amides of pyrrole- and thiophene-fused anthraquinone derivatives: A role of the heterocyclic core in antitumor properties. Eur J Med Chem. 2020 Aug 1;199:112294.

Molecular Formula	C₂₂H₁₉N₃O₅
Molecular Weight	405.40