2761366-60-1

2761366-60-1 structure

Name: BRD4 Inhibitor-15
Chemical Name: BRD4 Inhibitor-15
CAS Number: 2761366-60-1
Molecular Formula: C₂₂H₂₁N₃O₂
Molecular Weight: 359.42
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-08-10 23:32:21
Modify Date: 2024-01-10 20:15:17
BRD4 Inhibitor-15 (compound 13) is a potent BRD4 inhibitor, with an IC50 of 18 nM. BRD4 Inhibitor-15 induces apoptosis of 22RV1 cells by regulating Bcl-2/Bax proteins and activating caspase-3 signaling pathway. BRD4 Inhibitor-15 down-regulates the c-Myc level in 22RV1 cells. BRD4 Inhibitor-15 can be used for prostate cancer research[1].

Name	BRD4 Inhibitor-15

Description	BRD4 Inhibitor-15 (compound 13) is a potent BRD4 inhibitor, with an IC50 of 18 nM. BRD4 Inhibitor-15 induces apoptosis of 22RV1 cells by regulating Bcl-2/Bax proteins and activating caspase-3 signaling pathway. BRD4 Inhibitor-15 down-regulates the c-Myc level in 22RV1 cells. BRD4 Inhibitor-15 can be used for prostate cancer research[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Apoptosis >> Caspase Signaling Pathways >> Apoptosis >> c-Myc Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	BRD4(1):18 ± 1.1 nM (IC50) Bcl-2 Bax Caspase-3 Procaspase-3
In Vitro	BRD4 Inhibitor-15 (compound 13) shows potent anti-proliferative activity against enzalutamide-resistant 22RV1 cells and LNCap cells, with IC50 values of 8.27 ± 0.28 and 7.33 ± 0.49 μM, respectively[1].
References	[1]. Jiang W, et al. Design, synthesis, and evaluation of novel pyridone derivatives as potent BRD4 inhibitors for the potential treatment of prostate cancer. Bioorg Chem. 2022 Feb;119:105575.

Molecular Formula	C₂₂H₂₁N₃O₂
Molecular Weight	359.42