2411390-10-6

2411390-10-6 structure

Name: COX-2-IN-17
Chemical Name: COX-2-IN-17
CAS Number: 2411390-10-6
Molecular Formula: C₂₀H₂₃ClN₆O₂
Molecular Weight: 414.89
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2022-08-18 14:43:06
Modify Date: 2024-04-06 19:57:22
COX-2-IN-17 (compound 10) is a potent and BBB-penetrated COX-2 (cyclooxygenase-2) inhibitor, with an IC50 of 0.02 μM. COX-2-IN-17 shows anti-inflammatory and analgesic activities. COX-2-IN-17 attenuates hyperalgesia in the neurogenic phase as well as the inflammatory phase[1].

Name	COX-2-IN-17

Description	COX-2-IN-17 (compound 10) is a potent and BBB-penetrated COX-2 (cyclooxygenase-2) inhibitor, with an IC50 of 0.02 μM. COX-2-IN-17 shows anti-inflammatory and analgesic activities. COX-2-IN-17 attenuates hyperalgesia in the neurogenic phase as well as the inflammatory phase[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-2:0.02 μM (IC50) COX-1:>10 μM (IC50)
References	[1]. Kumari P, et al. Modification of the lead molecule: Tryptophan and piperidine appended triazines reversing inflammation and hyeperalgesia in rats. Bioorg Med Chem. 2020 Jan 15;28(2):115246.

Molecular Formula	C₂₀H₂₃ClN₆O₂
Molecular Weight	414.89