2417995-08-3

2417995-08-3 structure

2417995-08-3 structure

Name: COX-2-IN-23
Chemical Name: COX-2-IN-23
CAS Number: 2417995-08-3
Molecular Formula: C₂₄H₂₅N₅O₃S₂
Molecular Weight: 495.62
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2022-09-04 16:30:44
Modify Date: 2024-08-13 07:22:30
COX-2-IN-23 (compound 9a) is a selective COX-2 inhibitor with IC50 values of 0.28 and 20.14 μM for COX-2 and COX-1. COX-2-IN-23 has anti-inflammatory activity and low ulcerogenic activity.

Name	COX-2-IN-23

Description	COX-2-IN-23 (compound 9a) is a selective COX-2 inhibitor with IC50 values of 0.28 and 20.14 μM for COX-2 and COX-1. COX-2-IN-23 has anti-inflammatory activity and low ulcerogenic activity.
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-2:0.28 μM (IC50) COX-1:20.14 μM (IC50)
In Vivo	COX-2-IN-23 (compound 9a) (9 mg/kg; a single i.p.; 0-4 hours) exhibits anti-inflammatory activities and lowest incidence of pepticulcer[1]. Animal Model: Mature male albino rats[1] Dosage: 9 mg/kg Administration: Intraperitoneal injection; 0, 1, 2, 3 and 4 hours. Result: Had similar ulcerogenic activity to celecoxib.
References	[1]. Ibrahim TS, et al. Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on bumetanide scaffold. Bioorg Chem. 2020 Jul;100:103878.

Molecular Formula	C₂₄H₂₅N₅O₃S₂
Molecular Weight	495.62