2529451-43-0

2529451-43-0 structure

2529451-43-0 structure

Name: COX-2-IN-20
Chemical Name: COX-2-IN-20
CAS Number: 2529451-43-0
Molecular Formula: C₁₁H₉ClFN₃O₂
Molecular Weight: 269.66
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2022-09-02 14:31:36
Modify Date: 2024-07-21 10:45:40
COX-2-IN-20 (Compound 5d) is a selective and orally active COX-2 inhibitor with an IC50 of 17.9 nM. COX-2-IN-20 shows anti-inflammatory activity[1].

Name	COX-2-IN-20

Description	COX-2-IN-20 (Compound 5d) is a selective and orally active COX-2 inhibitor with an IC50 of 17.9 nM. COX-2-IN-20 shows anti-inflammatory activity[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-2:17.9 nM (IC50) COX-1:19.3 μM (IC50)
In Vitro	COX-2-IN-20 (Compound 5d) shows potential anti-inflammatory activity on NO inhibition in LPS-induced RAW 264.7 cell with an IC50 of 2.87 μM[1].
In Vivo	COX-2-IN-20 (Compound 5d) (5 mg/kg) exhibits better in vivo anti-inflammation and gastric protection than 10 mg/kg Indomethacin[1].
References	[1]. Li SM, et al. New methyl 5-(halomethyl)-1-aryl-1H-1,2,4-triazole-3-carboxylates as selective COX-2 inhibitors and anti-inflammatory agents: Design, synthesis, biological evaluation, and docking study. Bioorg Chem. 2020 Nov;104:104333.

Molecular Formula	C₁₁H₉ClFN₃O₂
Molecular Weight	269.66