1809163-24-3

1809163-24-3 structure

Name: HDAC-IN-43
Chemical Name: HDAC-IN-43
CAS Number: 1809163-24-3
Molecular Formula: C₂₂H₂₈N₆O₄
Molecular Weight: 440.50
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2022-09-08 12:42:53
Modify Date: 2024-04-06 16:38:21
HDAC-IN-43 is a potent HDAC 1/3/6 inhibitor with IC50 values of 82, 45, and 24 nM, respectively. HDAC-IN-43 is a weak PI3K/mTOR inhibitors with IC50 values of 3.6 and 3.7 μM, respectively. HDAC-IN-43 shows broad anti-proliferative activity [1].

Name	HDAC-IN-43

Description	HDAC-IN-43 is a potent HDAC 1/3/6 inhibitor with IC50 values of 82, 45, and 24 nM, respectively. HDAC-IN-43 is a weak PI3K/mTOR inhibitors with IC50 values of 3.6 and 3.7 μM, respectively. HDAC-IN-43 shows broad anti-proliferative activity [1].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC1:82 nM (IC50) HDAC2:358 nM (IC50) HDAC3:45 nM (IC50) HDAC6:24 nM (IC50) HDAC8:1441 nM (IC50) HDAC10:182 nM (IC50) HDAC11:9061 nM (IC50)
In Vitro	HDAC-IN-43 demonstrats broad anti-cancer activities against 38 cancer cell lines at 72 hours [1]. Cell Viability Assay Cell Line: K562, MOLT4, MV4-11, Raji, Ramos, SU-DHL-6, HepG2, HuH-7, PLC/PRF/5, SK-HEP1, SNU-387, SNU-398, MCF7 and PC-2[1] Concentration: 0.22-1.42 μM Incubation Time: 72 h Result: showed anti-cancer activities, the IC50 values of K562, MOLT4, MV4-11, Raji, Ramos, SU-DHL-6, HepG2, HuH-7, PLC/PRF/5, SK-HEP1, SNU-387, SNU-398, MCF7 and PC-2 are 0.22-1.42 μM[1].
References	[1]. Dizhong Chen, et al. Synthesis and biological evaluation of 6-phenylpurine linked hydroxamates as novel histone deacetylase inhibitors. Bioorg Chem. 2020 May;98:103724.

Molecular Formula	C₂₂H₂₈N₆O₄
Molecular Weight	440.50