2246363-68-6

2246363-68-6 structure

Name: β-Glucuronide-dPBD-PEG5-NH2
Chemical Name: β-Glucuronide-dPBD-PEG5-NH2
CAS Number: 2246363-68-6
Molecular Formula: C₇₈H₁₀₁N₇O₃₅
Molecular Weight: 1696.66
Catalog: Research Areas Cancer
Create Date: 2022-08-17 11:55:46
Modify Date: 2024-01-20 10:45:53
β-Glucuronide-dPBD-PEG5-NH2 is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD. β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2, as a prodrug of cIRCR201-dPBD, reduces side effects[1].

Name	β-Glucuronide-dPBD-PEG5-NH2

Description	β-Glucuronide-dPBD-PEG5-NH2 is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD. β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2, as a prodrug of cIRCR201-dPBD, reduces side effects[1].
Related Catalog	Research Areas >> Cancer
Target	Drug-linker conjugates for ADC, Apoptosis[1]
References	[1]. Byeongkwi Min, et al. cIRCR201-dPBD, a Novel Pyrrolobenzodiazepine Dimer-Containing Site-Specific Antibody-Drug Conjugate Targeting c-Met Overexpression Tumors. ACS Omega. 2020 Sep 29;5(40):25798-25809.

Molecular Formula	C₇₈H₁₀₁N₇O₃₅
Molecular Weight	1696.66