2246364-63-4

2246364-63-4 structure

Name: β-Glucuronide-dPBD-PEG5-NH2 TFA
Chemical Name: β-Glucuronide-dPBD-PEG5-NH2 TFA
CAS Number: 2246364-63-4
Molecular Formula: C₈₀H₁₀₂F₃N₇O₃₇
Molecular Weight: 1810.69
Catalog: Research Areas Cancer
Create Date: 2022-08-24 15:07:29
Modify Date: 2024-07-16 17:19:52
β-Glucuronide-dPBD-PEG5-NH2 TFA is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD.β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2 TFA, as a prodrug of cIRCR201-dPBD, reduces side effects[1].

Name	β-Glucuronide-dPBD-PEG5-NH2 TFA

Description	β-Glucuronide-dPBD-PEG5-NH2 TFA is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD.β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2 TFA, as a prodrug of cIRCR201-dPBD, reduces side effects[1].
Related Catalog	Research Areas >> Cancer
Target	Drug-linker conjugates for ADC, Apoptosis[1]
References	[1]. Byeongkwi Min, et al. cIRCR201-dPBD, a Novel Pyrrolobenzodiazepine Dimer-Containing Site-Specific Antibody-Drug Conjugate Targeting c-Met Overexpression Tumors. ACS Omega. 2020 Sep 29;5(40):25798-25809.

Molecular Formula	C₈₀H₁₀₂F₃N₇O₃₇
Molecular Weight	1810.69