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55683-37-9

55683-37-9 structure
55683-37-9 structure
  • Name: Propargyl-PEG1-acid
  • Chemical Name: 3-prop-2-ynoxypropanoic acid
  • CAS Number: 55683-37-9
  • Molecular Formula: C6H8O3
  • Molecular Weight: 128.12600
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2017-10-29 06:12:30
  • Modify Date: 2024-01-18 19:36:15
  • Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM[1].

Name 3-prop-2-ynoxypropanoic acid
Synonyms Propargyl-PEG1-acid
Description Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM[1].
Related Catalog
Target

PEGs

In Vitro BTK-CRBN PROTACs act as stoichiometric degraders, resulting in degradation of BTK protein. Degradation of BTK is a result of cereblon E3 ligases family recruitment[1].
References

[1]. Tinworth CP, et al. PROTAC-Mediated Degradation of Bruton's Tyrosine Kinase Is Inhibited by Covalent Binding. ACS Chem Biol. 2019 Mar 15;14(3):342-347.

Density 1.14g/cm3
Boiling Point 265.8ºC at 760 mmHg
Molecular Formula C6H8O3
Molecular Weight 128.12600
Flash Point 113.9ºC
Exact Mass 128.04700
PSA 46.53000
LogP 0.11090
Index of Refraction 1.463
Storage condition -20°C
Hazard Codes Xi