55683-37-9

55683-37-9 structure

Name: Propargyl-PEG1-acid
Chemical Name: 3-prop-2-ynoxypropanoic acid
CAS Number: 55683-37-9
Molecular Formula: C₆H₈O₃
Molecular Weight: 128.12600
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2017-10-29 06:12:30
Modify Date: 2024-01-18 19:36:15
Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM[1].

Name	3-prop-2-ynoxypropanoic acid
Synonyms	Propargyl-PEG1-acid

Description	Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	BTK-CRBN PROTACs act as stoichiometric degraders, resulting in degradation of BTK protein. Degradation of BTK is a result of cereblon E3 ligases family recruitment[1].
References	[1]. Tinworth CP, et al. PROTAC-Mediated Degradation of Bruton's Tyrosine Kinase Is Inhibited by Covalent Binding. ACS Chem Biol. 2019 Mar 15;14(3):342-347.

Hazard Codes	Xi

488150-84-1

55683-37-9