2562383-94-0

2562383-94-0 structure

Name: CYP3A4-IN-2
Chemical Name: CYP3A4-IN-2
CAS Number: 2562383-94-0
Molecular Formula: C₃₃H₃₈N₄O₃S
Molecular Weight: 570.74
Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
Create Date: 2022-09-04 19:30:08
Modify Date: 2024-08-09 15:12:00
CYP3A4-IN-2 is a specific inhibitor of cytochrome P450 3A4 (CYP3A4) with the IC50 value of 0.055 μM. CYP3A4-IN-2 is a ritonavir analogue with increased hydrophobicity of the R2 side group and stronger inhibitory effect compared to ritonavir. CYP3A4-IN-2 can be used as an antiviral agent and immunosuppressants[1].

Name	CYP3A4-IN-2

Description	CYP3A4-IN-2 is a specific inhibitor of cytochrome P450 3A4 (CYP3A4) with the IC50 value of 0.055 μM. CYP3A4-IN-2 is a ritonavir analogue with increased hydrophobicity of the R2 side group and stronger inhibitory effect compared to ritonavir. CYP3A4-IN-2 can be used as an antiviral agent and immunosuppressants[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Inflammation/Immunology
Target	CYP3A4:0.055 μM (IC50)
References	[1]. Eric R Samuels, et al. An increase in side-group hydrophobicity largely improves the potency of ritonavir-like inhibitors of CYP3A4. Bioorg Med Chem. 2020 Mar 15;28(6):115349. doi: 10.1016/j.bmc.2020.115349. Epub 2020 Jan 31.

Molecular Formula	C₃₃H₃₈N₄O₃S
Molecular Weight	570.74