1802998-75-9

1802998-75-9 structure

Name: Filgotinib maleate
Chemical Name: Filgotinib maleate
CAS Number: 1802998-75-9
Molecular Formula: C₂₅H₂₇N₅O₇S
Molecular Weight: 541.58
Catalog: Signaling Pathways Epigenetics JAK
Create Date: 2022-09-17 12:20:12
Modify Date: 2024-01-02 16:23:23
Filgotinib (maleate) is a selective and orally active JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM and 116 nM for JAK1, JAK2, JAK3 and TYK2, respectively. Filgotinib (maleate) can be used for rheumatoid arthritis (RA) and Crohn's disease research[1][2].

Name	Filgotinib maleate

Description	Filgotinib (maleate) is a selective and orally active JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM and 116 nM for JAK1, JAK2, JAK3 and TYK2, respectively. Filgotinib (maleate) can be used for rheumatoid arthritis (RA) and Crohn's disease research[1][2].
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Inflammation/Immunology
Target	JAK1:10 nM (IC50) JAK2:28 nM (IC50) JAK3:810 nM (IC50) Tyk2:116 nM (IC50)
In Vitro	Filgotinib (maleate) (1-10 μM) inhibits Th1 and Th2 differentiation in a dose-dependent manner[1].
References	[1]. Van Rompaey L, et, al. Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases. J Immunol. 2013 Oct 1;191(7):3568-77. [2]. Labetoulle R, et al. Filgotinib for the treatment of Crohn's disease. Expert Opin Investig Drugs. 2018 Mar;27(3):295-300.

Molecular Formula	C₂₅H₂₇N₅O₇S
Molecular Weight	541.58