2409072-27-9

2409072-27-9 structure

Name: HDAC6-IN-11
Chemical Name: HDAC6-IN-11
CAS Number: 2409072-27-9
Molecular Formula: C₁₉H₁₆N₂O₄
Molecular Weight: 336.34
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2022-08-31 18:36:09
Modify Date: 2024-09-16 11:29:26
HDAC6-IN-11 (Compound 9) is a selective HDAC6 inhibitor with the IC50 value of 20.7 nM. HDAC6-IN-11 has more than 300-fold selectivity over HDAC other isoforms. HDAC6-IN-11 shows anti-proliferative activities against cancer cells[1].

Name	HDAC6-IN-11

Description	HDAC6-IN-11 (Compound 9) is a selective HDAC6 inhibitor with the IC50 value of 20.7 nM. HDAC6-IN-11 has more than 300-fold selectivity over HDAC other isoforms. HDAC6-IN-11 shows anti-proliferative activities against cancer cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC6:20.7 nM (IC50) HDAC8:7750 nM (IC50)
In Vitro	HDAC6-IN-11 (0.44-6.68 μM, 48 h) treatment shows anti-proliferative activities against A549 and HCT116 cells[1]. HDAC6-IN-11 (0-20 μM, 48 h) treatment can increase the acetylation status of H3 and tubulin[1]. Cell Proliferation Assay[1] Cell Line: A549 and HCT116 cells Concentration: 0.44-6.68 μM Incubation Time: 48 hours Result: Showed anti-proliferative activities to A549 and HCT116 cells (GI50=3.2 and 1.82 μM, respectively). Western Blot Analysis[1] Cell Line: HCT116 cells Concentration: 0, 0.6, 1.25, 2.5, 5, 10 and 20 μM Incubation Time: 48 hours Result: Led to the increase of acetylation status of H3 and tubulin in a dose-dependent manner, and upregulated acetylated tubulin.
References	[1]. Shih-Wei Wang, et al. Synthesis and biological evaluation of 2-quinolineacrylamides. Bioorg Med Chem. 2020 Feb 1;28(3):115250.

Molecular Formula	C₁₉H₁₆N₂O₄
Molecular Weight	336.34