2374139-68-9

2374139-68-9 structure

Name: P-CAB agent 1
Chemical Name: P-CAB agent 1
CAS Number: 2374139-68-9
Molecular Formula: C₂₆H₂₃FN₄O
Molecular Weight: 426.49
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2022-09-12 10:06:18
Modify Date: 2024-04-06 21:04:59
P-CAB agent 1 (compound B19) is a highly potent potassium-competitive acid blocker agent with an IC50 value of 60.50 nM for H+/K+-ATPase. P-CAB agent 1 has acceptable oral absorption in rats. P-CAB agent 1 can be used for researching acid-related disorders (ARDs)[1].

Name	P-CAB agent 1

Description	P-CAB agent 1 (compound B19) is a highly potent potassium-competitive acid blocker agent with an IC50 value of 60.50 nM for H+/K+-ATPase. P-CAB agent 1 has acceptable oral absorption in rats. P-CAB agent 1 can be used for researching acid-related disorders (ARDs)[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	IC50: 60.50 nM (H+/K+-ATPase)[1]
In Vivo	P-CAB agent 1 has acceptable oral absorption in rats[1]. Pharmacokinetic Parameters of P-CAB agent 1 in female Sprague-Dawley rats[1]. IV (2 mg/kg) PO (8 mg/kg) AUC0-∞ (ug/L*hr) 519.57 341.49 t1/2 (ng/mL) 0.49 0.8 Cmax (ug/L) 149.93 17 F (%) 16.43
References	[1]. Wang X, et al. Design, synthesis and biological evaluation of novel 5-methyl-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole derivatives as potent potassium-competitive acid blockers. Bioorg Med Chem. 2022 Jun 15;64:116765.

Molecular Formula	C₂₆H₂₃FN₄O
Molecular Weight	426.49