1257641-15-8

1257641-15-8 structure

1257641-15-8 structure

Name: PPARδ/γ agonist 1
Chemical Name: PPARδ/γ agonist 1
CAS Number: 1257641-15-8
Molecular Formula: C₂₅H₂₇NO₅
Molecular Weight: 421.49
Catalog: Signaling Pathways Cell Cycle/DNA Damage PPAR
Create Date: 2022-09-11 13:42:52
Modify Date: 2024-01-15 07:19:15
DB-959 (T3D-959 (free base)) is a potent dual PPAR delta/gamma inhibitor. DB-959 can be used for Alzheimer’s disease research[1].

Name	PPARδ/γ agonist 1

Description	DB-959 (T3D-959 (free base)) is a potent dual PPAR delta/gamma inhibitor. DB-959 can be used for Alzheimer’s disease research[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Neurological Disease
In Vivo	DB-959 (T3D-959 (free base)) (1 mg/kg; i.g.; daily, for 16 days; STZ-mediated Long Evans rats) restores STZ-mediated impairments of motor function[1]. Animal Model: STZ-mediated Long Evans rats[1] Dosage: 1 mg/kg Administration: Oral gavage; daily, for 16 days Result: Improved performance in the STZ-mediated rats and had neuroprotective for both granule and Purkinje cells.
References	[1]. Tong M, et, al. T3D-959: A Multi-Faceted Disease Remedial Drug Candidate for the Treatment of Alzheimer's Disease. J Alzheimers Dis. 2016;51(1):123-38.

Molecular Formula	C₂₅H₂₇NO₅
Molecular Weight	421.49