Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 9,19-Cyclopregnan-16-ol,14-methyl-3,20-bis(methylamino)-4-methylene-, (3b,5a,16a,20S)-
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2241-90-9

2241-90-9 structure

Name: Cyclobuxine D
Chemical Name: cyclobuxine-d
CAS Number: 2241-90-9
Molecular Formula: C₂₅H₄₂N₂O
Molecular Weight: 386.61400
Catalog: Signaling Pathways GPCR/G Protein mAChR
Create Date: 2018-05-29 08:00:00
Modify Date: 2024-01-08 21:43:25
Cyclobuxine D is a steroidal alkaloid extracted from Buxus microphylla. Cyclobuxine D has a significant bradycardic effect in the rat heart and an inhibitory action on acetylcholine and Ba++−induced contraction of the longitudinal muscle isolated from the rabbit jejunum[1][2].

Name	cyclobuxine-d
Synonyms	cyclobuxine cyclobuxine D (3beta,5alpha,16alpha,20S)-14-Methyl-3,20-bis(methylamino)-4-methylene-9,19-cyclopregnan-16-ol

Description	Cyclobuxine D is a steroidal alkaloid extracted from Buxus microphylla. Cyclobuxine D has a significant bradycardic effect in the rat heart and an inhibitory action on acetylcholine and Ba++−induced contraction of the longitudinal muscle isolated from the rabbit jejunum[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Inflammation/Immunology
References	[1]. . A. Eshonov, et al. Alkaloids of Buxus sempervirens, Crystal and Molecular Structure of Cyclobuxine-D and Imperialine. Chemistry of Natural Compounds. 12 January 2014. 49:11791182. [2]. Kwon, Jun-Tack, et al. Effects of Cyclobuxine D on Drug-Induced Contractions of the Isolated Rat Uterine Muscle and Potassium-Activated Calcium Channels in an Intestinal Smooth Muscle. The Korean Journal of Pharmacology. 1988. 24 (1): 103-109.

CHEMICAL NAME :: 9,19-Cyclo-5-alpha,9-beta-pregnan-16-alpha-ol, 14-methyl-3-beta,20-alpha-bis(methylamino)-4- methylene-

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(2),217,1982