2581824-39-5
2581824-39-5 structure
- Name: MMP-9-IN-4
- Chemical Name: MMP-9-IN-4
- CAS Number: 2581824-39-5
- Molecular Formula: C28H19F3N4O6
- Molecular Weight: 564.47
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2022-10-16 08:22:24
- Modify Date: 2024-01-11 12:50:45
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MMP-9-IN-4 is a MMP-9 inhibitor (IC50: 7.46 nM) that has H-π interactions with MMP-9. MMP-9-IN-4 also inhibits AKT activity (IC50: 8.82 nM). MMP-9-IN-4 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-4 can be used in the research of cancers[1].
| Name | MMP-9-IN-4 |
|---|
| Description | MMP-9-IN-4 is a MMP-9 inhibitor (IC50: 7.46 nM) that has H-π interactions with MMP-9. MMP-9-IN-4 also inhibits AKT activity (IC50: 8.82 nM). MMP-9-IN-4 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-4 can be used in the research of cancers[1]. |
|---|---|
| Related Catalog | |
| Target |
MMP-9:7.46 nM (IC50) MMP-1:41 nM (IC50) MMP-2:139 nM (IC50) MMP-13:113 nM (IC50) AKT:8.82 nM (IC50) |
| In Vitro | MMP-9-IN-4 (compound 11, 0-1 μM approximately, 72 h) shows cytotoxicity to Wi-38, MCF-7, NFS-60, HepG-2 cells[1]. MMP-9-IN-4 (72 h) induces apoptosis in MCF-7, NFS-60 and HepG-2 cells at 3.6 nM, 3.61 nM, 2.2 nM respectively[1]. MMP-9-IN-4 (72 h) induces significant caspase 3/7 activation in MCF-7, NFS-60 and HepG-2 cells at 3.6 nM, 3.61 nM, 2.2 nM respectively [1]. MMP-9-IN-4 (2.2 nM, 24 h) inhibits cell migration in HepG-2 cells[1]. MMP-9-IN-4 has anti-bacterial activity against E.coli with a MIC value of 1.814 μM[1]. Cell Viability Assay[1] Cell Line: Wi-38, MCF-7, NFS-60, HepG-2 cells Concentration: 0-1 μM approximately Incubation Time: 72 h Result: Showed cytotoxicity with IC50s: 374 nM (Wi-38), 3.6 nM (MCF-7), 3.61 nM (NFS-60), 2.2 nM (HepG-2). Cell Migration Assay [1] Cell Line: HepG-2 Concentration: 2.2 nM Incubation Time: 24 h Result: Inhibited cell migration by 93.77%. |
| References |
| Molecular Formula | C28H19F3N4O6 |
|---|---|
| Molecular Weight | 564.47 |