1957-01-3
1957-01-3 structure
- Name: CCR4 antagonist 3-1
- Chemical Name: CCR4 antagonist 3-1
- CAS Number: 1957-01-3
- Molecular Formula: C14H12N2S
- Molecular Weight: 240.32
- Catalog: Signaling Pathways GPCR/G Protein CCR
- Create Date: 2022-11-21 17:21:37
- Modify Date: 2024-04-03 12:17:18
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CCR4 antagonist 3 is a potent chemokine receptor 4 (CCR4) antagonist with an IC50 value of 1.7 μM for [125I]TARC (thymus and activation regulated chemokine). CCR4 antagonist 3 inhibits binding of radiolabeled TARC and macrophage-derived chemokine (MDC) to CCR4 receptors on the surface of CEM cells. CCR4 antagonist 3 also inhibits the in vitro migration of CEM cells mediated by TARC (IC50 = 6.4 μM)[1].
| Name | CCR4 antagonist 3-1 |
|---|
| Description | CCR4 antagonist 3 is a potent chemokine receptor 4 (CCR4) antagonist with an IC50 value of 1.7 μM for [125I]TARC (thymus and activation regulated chemokine). CCR4 antagonist 3 inhibits binding of radiolabeled TARC and macrophage-derived chemokine (MDC) to CCR4 receptors on the surface of CEM cells. CCR4 antagonist 3 also inhibits the in vitro migration of CEM cells mediated by TARC (IC50 = 6.4 μM)[1]. |
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| Related Catalog | |
| Target |
CCR4 [125I]-TARC-CCR4:1.7 μM (IC50) |
| In Vivo | CCR4 antagonist 3 (compound 1) (0.5 mg/kg for IV; 2 mg/kg for PO; single dosage) exhibits a high clearance, short half-life and low oral bioavailability[1]. Animal Model: Rats[1] Dosage: 0.5 mg/kg for IV; 2 mg/kg for PO Administration: IV and PO; single dosage Result: Exhibited a high clearance of 4.2 L/h/kg and a short half-life of 0.4 h, and the oral bioavailability of 2%. |
| References |
| Molecular Formula | C14H12N2S |
|---|---|
| Molecular Weight | 240.32 |