1187852-48-7

1187852-48-7 structure

Name: SOR-C13
Chemical Name: SOR-C13
CAS Number: 1187852-48-7
Molecular Formula: C₇₂H₁₁₆N₂₀O₁₉
Molecular Weight: 1565.81
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
Create Date: 2022-11-21 09:51:39
Modify Date: 2024-04-07 18:13:16
SOR-C13, a carboxy-terminal truncated peptide, is a high-affinity TRPV6 antagonist with an IC50 value of 14 nM. TRPV6 is a non-voltage gated calcium channel that is associated with malignancy and poor prognosis in breast cancer. SOR-C13 has anticancer activity[1].

Name	SOR-C13

Description	SOR-C13, a carboxy-terminal truncated peptide, is a high-affinity TRPV6 antagonist with an IC50 value of 14 nM. TRPV6 is a non-voltage gated calcium channel that is associated with malignancy and poor prognosis in breast cancer. SOR-C13 has anticancer activity[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cancer
In Vivo	SOR-C13 (i.p.; 400,600 or 800 mg/kg; daily; on days 1 to 12) can effectively inhibit the growth of tumor in female NOD/SCID mice with SKOV-3 cell[2].
References	[1]. S Fu , et al. Erratum to: First-in-human phase I study of SOR-C13, a TRPV6 calcium channel inhibitor, in patients with advanced solid tumors. Invest New Drugs. 2017 Jun;35(3):397. [2]. Hui Xue, et al. Inhibition of Transient Receptor Potential Vanilloid 6 channel, elevated in human ovarian cancers, reduces tumour growth in a xenograft model. J Cancer. 2018 Aug 6;9(17):3196-3207.

Molecular Formula	C₇₂H₁₁₆N₂₀O₁₉
Molecular Weight	1565.81