327104-77-8

327104-77-8 structure

Name: Sirtuin modulator 4
Chemical Name: WAY-603231
CAS Number: 327104-77-8
Molecular Formula: C₁₈H₁₀N₂O₂S
Molecular Weight: 318.35
Catalog: Signaling Pathways Cell Cycle/DNA Damage Sirtuin
Create Date: 2022-11-26 19:51:08
Modify Date: 2024-04-03 22:51:25
Sirtuin modulator 4 (compound 12) is a sirtuin modulator. Sirtuin modulator 4 shows inhibitory effect to SIRT1 with an EC50 value of 51-100 μM. Sirtuin modulator 4 may be used for the research of increasing the lifespan of a cell, and preventing a wide variety of diseases and disorders including, for example, diabetes, obesity, neurodegenerative diseases, cardiovascular diseases, inflammation and cancer[1].

Name	WAY-603231
Synonyms	2-Benzothiazoleacetonitrile, α-(2-benzofuranylcarbonyl)-

Description	Sirtuin modulator 4 (compound 12) is a sirtuin modulator. Sirtuin modulator 4 shows inhibitory effect to SIRT1 with an EC50 value of 51-100 μM. Sirtuin modulator 4 may be used for the research of increasing the lifespan of a cell, and preventing a wide variety of diseases and disorders including, for example, diabetes, obesity, neurodegenerative diseases, cardiovascular diseases, inflammation and cancer[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Sirtuin Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	SIRT1:51-100 μM (EC50)
In Vitro	Sirtuin modulator 4 (0.7-100 μM) inhibits SIRT1 with an EC50 value of 51-100 μM[1].
References	[1]. Milburn Michael, et al. Fused heterocyclic compounds and their use as sirtuin modulators. US7998974. 2011.

Molecular Formula	C₁₈H₁₀N₂O₂S
Molecular Weight	318.35