Name | (25R)-5β-spirostan-3β-ol |
---|---|
Synonyms |
(25R)-5beta-spirostan-3beta-ol
ISOSARSAPOGENIN (25R)-SPIROSTAN-3BETA-OL SMILAGENIN EINECS 204-775-8 (25R)-Spirostan-3.β.-ol ESMILAGENIN ISOSARSAPOGENINE ISOSARSASAPOGENIN MFCD00037845 25R,5BETA-SPIROSTAN-3BETA-OL |
Description | Smilagenin (SMI) is a lipid-soluble small-molecule steroidal sapogenin from Rhizoma anemarrhenae and Radix asparagi widely used in traditional Chinese medicine for treating chronic neurodegeneration diseases[1]. Smilagenin (SMI) improves memory of aged rats by increasing the muscarinic receptor subtype 1 (M1)-receptor density[2].Smilagenin (SMI) attenuates Aβ(25-35)-induced neurodegenerationvia stimulating the gene expression of brain-derived neurotrophic factor, may represents a novel therapeutic strategy for AD[3]. |
---|---|
Related Catalog | |
In Vitro | Smilagenin (10 μM; 24 hours) increases SH-SY5Y cell survival compared with Aβ(25-35) intoxicated cells[3]. Smilagenin (10 μM; 24 hours) increases neurotrophic factor (GDNF) and neurotrophic factor (BDNF) mRNA level by promoting CREB phosphorylation in 1-methyl-4-phenylpyridimium (MPP+) treated SH-SY5Y cells[2]. Cell Viability Assay[3] Cell Line: SH-SY5Y cells Concentration: 10 μM Incubation Time: 24 hours Result: Elevated the SH-SY5Y cell viability. RT-PCR[2] Cell Line: SH-SY5Y cells Concentration: 10 μM Incubation Time: 24 hours Result: Increased GDNF and BDNF transcription. |
In Vivo | Smilagenin (intragastric administration; 10 or 26 mg/kg, once daily; 60 days) prevents the impairment of dopaminergic neurons in chronic MPTP/probenecid-induced mouse model[2]. Animal Model: MPTP/probenecid-induced mouse model[2] Dosage: 10 or 26 mg/kg Administration: Intragastric administration; 10 or 26 mg/kg; once daily; 60 days Result: Ameliorated locomotor ability of MPTP/probenecid-lesioned mice. |
References |
Density | 1.11g/cm3 |
---|---|
Boiling Point | 516.6ºC at 760mmHg |
Melting Point | -185ºC |
Molecular Formula | C27H44O3 |
Molecular Weight | 416.63600 |
Flash Point | 266.2ºC |
Exact Mass | 416.32900 |
PSA | 38.69000 |
LogP | 5.79380 |
Vapour Pressure | 7.83E-13mmHg at 25°C |
Index of Refraction | 1.552 |
Storage condition | 2-8℃ |
WGK Germany | 3 |
---|