2883535-99-5

2883535-99-5 structure

Name: c-Myc inhibitor 7
Chemical Name: c-Myc inhibitor 7
CAS Number: 2883535-99-5
Molecular Formula: C₃₅H₃₀N₆O₅
Molecular Weight: 614.65
Catalog: Signaling Pathways Apoptosis c-Myc
Create Date: 2023-04-04 17:52:04
Modify Date: 2024-02-27 18:15:53
c-Myc inhibitor 7 is a c-Myc inhibitor and a multiple target protein degrader. c-Myc inhibitor 7 effective degrades c-MYC, CK1α, GSPT1 and IKZF1/2/3 proteins in a variety of tumor cells. c-Myc inhibitor 7 can be used for c-Myc high expression related disease research, such as cancer, cardiovascular and cerebrovascular diseases, and viral infection[1].

Name	c-Myc inhibitor 7

Description	c-Myc inhibitor 7 is a c-Myc inhibitor and a multiple target protein degrader. c-Myc inhibitor 7 effective degrades c-MYC, CK1α, GSPT1 and IKZF1/2/3 proteins in a variety of tumor cells. c-Myc inhibitor 7 can be used for c-Myc high expression related disease research, such as cancer, cardiovascular and cerebrovascular diseases, and viral infection[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Research Areas >> Infection Signaling Pathways >> Apoptosis >> c-Myc Signaling Pathways >> Cell Cycle/DNA Damage >> Casein Kinase Signaling Pathways >> Stem Cell/Wnt >> Casein Kinase
In Vitro	c-Myc inhibitor 7 (0-10 mM；3 天) 抑制 HL60 细胞增殖，IC50 值为 0.5 nM[1]。 c-Myc inhibitor 7 促进 60-90% HL60 细胞中蛋白的降解[1]。 c-Myc inhibitor 7 (1，3，10 和 100 nM；24 小时) 在多种细胞系中降解 c-Myc，CKla，GSPTl，IKZFl，IKZF2 和 IKZF3 蛋白[1]。
References	[1]. TONG YOUZHI, et al. 2,6-Dioxopiperidine compounds as c-Myc inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases. WO2022268066. 2022.

Molecular Formula	C₃₅H₃₀N₆O₅
Molecular Weight	614.65