2876918-68-0

2876918-68-0 structure

Name: CB2R/FAAH modulator-2
Chemical Name: CB2R/FAAH modulator-2
CAS Number: 2876918-68-0
Molecular Formula: C₂₄H₃₃NO₂
Molecular Weight: 367.52
Catalog: Signaling Pathways GPCR/G Protein Cannabinoid Receptor
Create Date: 2023-04-30 10:44:42
Modify Date: 2024-01-12 09:41:51
CB2R/FAAH modulator-2 (compound 26) is a dual targeting modulator that acts as a CB2R agonist and FAAH inhibitor. The Ki values for CB2R/FAAH modulator-2 are 10.8 and 152.9 nM for CB2R and CB1R, respectively, and the IC50 value for FAAH is 6.2 μM. CB2R/FAAH modulator-2 can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection[1].

Name	CB2R/FAAH modulator-2

Description	CB2R/FAAH modulator-2 (compound 26) is a dual targeting modulator that acts as a CB2R agonist and FAAH inhibitor. The Ki values for CB2R/FAAH modulator-2 are 10.8 and 152.9 nM for CB2R and CB1R, respectively, and the IC50 value for FAAH is 6.2 μM. CB2R/FAAH modulator-2 can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> FAAH Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> FAAH Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor
Target	CB1:152.9 nM (Ki) CB2:10.8 nM (Ki)
In Vitro	CB2R/FAAH modulator-2 (compound 26)(10 μM) 在未刺激的单核细胞和巨噬细胞中，可以降低促炎细胞因子 TNFα、IFN-γ、IL-1β 和 IL6 的产生[1]。
References	[1]. Francesca Intranuovo, et al. Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase. J Med Chem. 2023 Jan 12;66(1):235-250.

Molecular Formula	C₂₄H₃₃NO₂
Molecular Weight	367.52