445416-12-6

445416-12-6 structure

Name: NSD3-IN-3
Chemical Name: NSD3-IN-3
CAS Number: 445416-12-6
Molecular Formula: C₁₅H₁₇N₅O₂S
Molecular Weight: 331.39
Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
Create Date: 2023-05-11 19:38:41
Modify Date: 2024-04-06 00:14:21
NSD3-IN-3 is a potent NSD3 inhibtor with an IC50 value of 1.86 μM. NSD3-IN-3 has anticancer activity and significantly inhibits the growth and proliferation of non-small cell lung cancer cell line H460[1].

Name	NSD3-IN-3

Description	NSD3-IN-3 is a potent NSD3 inhibtor with an IC50 value of 1.86 μM. NSD3-IN-3 has anticancer activity and significantly inhibits the growth and proliferation of non-small cell lung cancer cell line H460[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Methyltransferase
Target	NSD3:1.86 μM (IC50)
In Vitro	NSD3-IN-3 (化合物 B2) (0-10 μM; 48 h) 在 10 μM 下完全抑制 H460 和 H1299 细胞中 H3K36me3 修饰[1]。 NSD3-IN-3 (0-20 μM; 48 h) 抑制 H460 细胞的生长[1]。 Cell Viability Assay[1] Cell Line: Non-small cell lung cancer cell line H460 Concentration: 0, 2.5, 5, 10, and 20 μM Incubation Time: 48 hours Result: Inhibited cell growth dose-dependently.
References	[1]. Kong Ren, et al. Application of compound B2 as histone methyltransferase NSD3 inhibitor: China, CN109223795[P].2019-01-18.

Molecular Formula	C₁₅H₁₇N₅O₂S
Molecular Weight	331.39