1042780-52-8

1042780-52-8 structure
1042780-52-8 structure
  • Name: PARP10-IN-2
  • Chemical Name: PARP10-IN-2
  • CAS Number: 1042780-52-8
  • Molecular Formula: C14H10N2O2
  • Molecular Weight: 238.24
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage PARP
  • Create Date: 2023-04-05 12:00:46
  • Modify Date: 2024-01-14 09:38:23
  • PARP10-IN-2 is a potent mono‐ADP‐ribosyltransferase PARP10 inhibitor with an IC50 of 3.64 μM for human PARP10. PARP10-IN-2 reveals potent inhibition on PARP2 and PARP15 with IC50s of 27 μM and 11 μM for human PARP2 and human PARP15, respectively[1].

Name PARP10-IN-2
Description PARP10-IN-2 is a potent mono‐ADP‐ribosyltransferase PARP10 inhibitor with an IC50 of 3.64 μM for human PARP10. PARP10-IN-2 reveals potent inhibition on PARP2 and PARP15 with IC50s of 27 μM and 11 μM for human PARP2 and human PARP15, respectively[1].
Related Catalog
Target

human PARP10:3.64 μM (IC50)

human PARP15:11 μM (IC50)

human PARP2:27 μM (IC50)

human PARP12:>10 μM (IC50)

human PARP16:>10 μM (IC50)

human PARP1:>100 μM (IC50)

human PARP3:>100 μM (IC50)

human PARP4:>100 μM (IC50)

human TNKS1:>100 μM (IC50)

human TNKS2:>100 μM (IC50)

human PARP14:>100 μM (IC50)

In Vitro PARP10-IN-2 (化合物 10) 在 HeLa-PARP10 细胞中通过克隆形成测定 (CFA) 的 IC50 为 1-2 μM[1]。
References

[1]. Patricia Korn, et al. Evaluation of 3- and 4-Phenoxybenzamides as Selective Inhibitors of the Mono-ADP-Ribosyltransferase PARP10. ChemistryOpen. 2021 Oct;10(10):939-948.  

Molecular Formula C14H10N2O2
Molecular Weight 238.24