655237-16-4
655237-16-4 structure
- Name: YM543 free base
- Chemical Name: YM543 free base
- CAS Number: 655237-16-4
- Molecular Formula: C23H24O6
- Molecular Weight: 396.43
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel SGLT
- Create Date: 2023-04-05 17:27:02
- Modify Date: 2024-08-09 11:01:19
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YM543 free base is a potent and orally active sodium-glucose cotransporter (SGLT) 2 inhibitor. YM543 free base reduces blood glucose levels. YM543 free base can be used in research of diabetes[1][2].
| Name | YM543 free base |
|---|
| Description | YM543 free base is a potent and orally active sodium-glucose cotransporter (SGLT) 2 inhibitor. YM543 free base reduces blood glucose levels. YM543 free base can be used in research of diabetes[1][2]. |
|---|---|
| Related Catalog | |
| Target |
SGLT2 |
| In Vivo | YM543 free base (0-3 mg/kg; p.o.) 在 KK/Ay 2 型糖尿病小鼠中降低血糖水平并改善葡萄糖耐量，同时增加尿糖排泄，效果甚至在 12 小时后仍持续[1]。 Animal Model: KK/Ay 2 diabetic mice[1] Dosage: 0.1, 0.3, 1, and 3 mg/kg Administration: oral administration Result: Had a strong and sustained antihyperglycemic effect in both KK/Ay type 2 diabetic mice. Animal Model: Male Sprague–Dawley rats[1] Dosage: 1.0 and 3.0 mg/kg Administration: intravenous injection (1.0 mg/kg) and oral administration (3.0 mg/kg) Result: 1.19 Administration iv (1 mg/kg) po (3 mg/kg) T1/2 (h) 0.9 1.3 CLtot (L/h/kg) 2483 Vdss (L/kg) 3360 Cmax (ng/mL) 101 Tmax (h) 0.5 AUC0-inf (ng h/mL) 403 F % 29 |
| References |
| Molecular Formula | C23H24O6 |
|---|---|
| Molecular Weight | 396.43 |