1688684-07-2
1688684-07-2 structure
- Name: MPX-004
- Chemical Name: MPX-004
- CAS Number: 1688684-07-2
- Molecular Formula: C17H15ClFN5O3S2
- Molecular Weight: 455.91
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
- Create Date: 2023-04-21 19:47:58
- Modify Date: 2024-01-30 14:34:13
-
MPX-004 is a potent GluN2A antagonist. MPX-004 inhibits GluN2A-containing NMDA receptors expressed in HEK cells with an IC50 of 79 nM. MPX-004 has no inhibitory effect on GluN2B or GluN2D receptor-mediated responses. MPX-004 has the potential for neuropsychiatric and developmental disorders research[1].
| Name | MPX-004 |
|---|
| Description | MPX-004 is a potent GluN2A antagonist. MPX-004 inhibits GluN2A-containing NMDA receptors expressed in HEK cells with an IC50 of 79 nM. MPX-004 has no inhibitory effect on GluN2B or GluN2D receptor-mediated responses. MPX-004 has the potential for neuropsychiatric and developmental disorders research[1]. |
|---|---|
| Related Catalog | |
| Target |
NMDA Receptor |
| In Vitro | MPX-004 抑制表达人 GluN1+GluN2A 的 Xenopus 卵母细胞中 NMDA 受体介导的电流，IC50 为 198 nM。在 10 μM 时，MPX-004 仅微弱地抑制表达 GluN2B、C 或 D 受体的卵母细胞或对照卵母细胞中的电流 (约8%)[1]。 MPX-004 (100 nM-30 μM; 0-50 分钟) 在 3 至 4 周龄大鼠大脑制备的海马切片导致 CA1 区 NMDA 受体介导的 fEPSP 浓度依赖性降低，以响应 Schaffer 侧支刺激[1]。 MPX-004 (1 μM) 抑制 5-HT1B 拮抗剂结合 (35%)，5-HT2A 激动剂结合 (31%) 和 EP4 激动剂结合 (27%)。MPX-004 (50 μM) 对小鼠视觉皮层电流切片中锥体神经元的 AMPA 受体介导的突触电流没有影响[1]。 |
| References |
| Molecular Formula | C17H15ClFN5O3S2 |
|---|---|
| Molecular Weight | 455.91 |