2671004-41-2

2671004-41-2 structure

Name: PROTAC MEK1 Degrader-1
Chemical Name: PROTAC MEK1 Degrader-1
CAS Number: 2671004-41-2
Molecular Formula: C₅₃H₆₆FIN₈O₁₁S₂
Molecular Weight: 1201.17
Catalog: Signaling Pathways MAPK/ERK Pathway ERK
Create Date: 2023-09-19 14:18:15
Modify Date: 2024-01-28 18:39:20
PROTAC MEK1 Degrader-1 is a PROTAC targeting MEK1 with a pIC50 value of 7.0. PROTAC MEK1 Degrader-1 consists of a MEK1 inhibitor and a von Hippel-Lindau ligand. PROTAC MEK1 Degrader-1 can inhibit ERK1/2 phosphorylation. PROTAC MEK1 Degrader-1 shows an antiproliferative activity against A375 cells[1].

Name	PROTAC MEK1 Degrader-1

Description	PROTAC MEK1 Degrader-1 is a PROTAC targeting MEK1 with a pIC50 value of 7.0. PROTAC MEK1 Degrader-1 consists of a MEK1 inhibitor and a von Hippel-Lindau ligand. PROTAC MEK1 Degrader-1 can inhibit ERK1/2 phosphorylation. PROTAC MEK1 Degrader-1 shows an antiproliferative activity against A375 cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> MEK Signaling Pathways >> PROTAC >> PROTAC Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK
References	[1]. Vollmer S, et al. Design, Synthesis, and Biological Evaluation of MEK PROTACs. J Med Chem. 2020 Jan 9;63(1):157-162.

Molecular Formula	C₅₃H₆₆FIN₈O₁₁S₂
Molecular Weight	1201.17