Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 3-Carboxy Detomidine
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3-(1H-IMIDAZOL-4-YLMETHYL)-2-METHYL-BENZOIC ACID
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

115664-39-6

115664-39-6 structure

Name: Detomidine carboxylic acid
Chemical Name: 3-Carboxy Detomidine
CAS Number: 115664-39-6
Molecular Formula: C₁₂H₁₂N₂O₂
Molecular Weight: 216.236
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2017-04-23 04:53:02
Modify Date: 2024-01-16 18:30:52
Detomidine carboxylic acid is the major urinary metabolite of Detomidine. Detomidine is a synthetic α2-adrenergic agonist and an animal analgesic sedative. Detomidine also has cardiac and respiratory effects and an antidiuretic action[1][2].

Name	3-Carboxy Detomidine
Synonyms	3-(1H-Imidazol-5-ylmethyl)-2-methylbenzoic acid Benzoic acid, 3-(1H-imidazol-5-ylmethyl)-2-methyl-

Description	Detomidine carboxylic acid is the major urinary metabolite of Detomidine. Detomidine is a synthetic α2-adrenergic agonist and an animal analgesic sedative. Detomidine also has cardiac and respiratory effects and an antidiuretic action[1][2].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
Target	α2-adrenergic[2]
In Vivo	Horse urine is investigated for metabolites following the oral administration of the large animal analgesic sedative Detomidine to two stallions and intravenous administration of [3H]-Detomidine to a mare. Detomidine carboxylic acid and hydroxydetomidine glucuronic acid conjugate are identified in the urine after the oral doses. About half of the radioactivity of [3H]-Detomidine is excreted in the urine in 12 h after the i.v. dose (80 μg/kg). Most of the excretion occurred between 5 and 12 h in contrast to urine output which is highest 2-5 h after the dosing. The major radioactive metabolite in the urine is Detomidine carboxylic acid. Detomidine carboxylic acid comprises more than two thirds of the total metabolites in all the urine fractions collected[1].
References	[1]. Salonen JS, et al. Identification of detomidine carboxylic acid as the major urinary metabolite of detomidine in the horse. Eur J Drug Metab Pharmacokinet. 1992 Jan-Mar;17(1):13-20. [2]. Virtanen R, et al. Pharmacological evidence for the involvement of alpha-2 adrenoceptors in the sedative effect of detomidine, a novel sedative-analgesic. J Vet Pharmacol Ther. 1985 Mar;8(1):30-7.

Density	1.3±0.1 g/cm3
Boiling Point	499.6±33.0 °C at 760 mmHg
Molecular Formula	C₁₂H₁₂N₂O₂
Molecular Weight	216.236
Flash Point	255.9±25.4 °C
Exact Mass	216.089874
PSA	65.98000
LogP	1.97
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.625

115664-39-6	39925-19-4
97729-56-1	441741-66-8
110988-79-9	1242137-15-0
40452-20-8	173536-74-8
90141-25-6	108992-66-1
1158522-08-7	890632-76-5
940364-43-2	113103-81-4
134104-43-1	131615-57-1
6906-52-1	930439-75-1
953140-91-5	1018584-77-4