941685-37-6
941685-37-6 structure
- Name: S-Ruxolitinib
- Chemical Name: S-Ruxolitinib
- CAS Number: 941685-37-6
- Molecular Formula: C17H18N6
- Molecular Weight: 306.365
- Catalog: Biochemical Inhibitor Tyrosine protein kinase/signal transducer and transcriptional activator inhibitor (JAK/STAT) JAK inhibitor
- Create Date: 2018-08-04 16:35:46
- Modify Date: 2024-01-13 19:40:08
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Ruxolitinib S enantiomer is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays.
| Name | S-Ruxolitinib |
|---|---|
| Synonyms |
1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (βS)-
ent-Ruxolitinib (3S)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Ruxolitinib (S enantiomer) (3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (S)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile INCB018424 |
| Description | Ruxolitinib S enantiomer is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays. |
|---|---|
| Related Catalog |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 592.6±50.0 °C at 760 mmHg |
| Molecular Formula | C17H18N6 |
| Molecular Weight | 306.365 |
| Flash Point | 312.2±30.1 °C |
| Exact Mass | 306.159302 |
| PSA | 83.18000 |
| LogP | 1.69 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.747 |
| Storage condition | -20℃ |