66504-40-3
66504-40-3 structure
- Name: 1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane
- Chemical Name: 1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane
- CAS Number: 66504-40-3
- Molecular Formula: C11H11Cl2N
- Molecular Weight: 228.12
- Catalog: Signaling Pathways Neuronal Signaling Dopamine Transporter
- Create Date: 2017-10-19 20:52:20
- Modify Date: 2024-01-09 12:43:13
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DOV-216,303 (Free Base) is a potent triple serotonin, norepinephrine, and dopamine reuptake inhibitor, with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively[1]. Has antidepressant-like effects and increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats[2].
| Name | 1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane |
|---|---|
| Synonyms |
dotriacontanedioic acid dichloride
dotricontanedioyl dichloride Dotriacontan-disaeure-dichlorid |
| Description | DOV-216,303 (Free Base) is a potent triple serotonin, norepinephrine, and dopamine reuptake inhibitor, with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively[1]. Has antidepressant-like effects and increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats[2]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 14 nM (serotonin), 20 nM (norepinephrine), 78 nM (dopamine)[1]. |
| In Vivo | Acute treatment of DOV-216,303 (20 mg/kg, i.p.) significantly increases dopamine, norepinephrine and serotonin levels in both OBX and Sham animals[2]. Chronic treatment with DOV 216,303 (20 mg/kg, i.p., for 17 days) increases extracellular concentrations of dopamine, norepinephrine and serotonin in the medial prefrontal cortex of both OBX and Sham animals and significantly increases extracellular baseline serotonin concentrations[2]. Animal Model: Male Sprague Dawley rats weighing between 290 and 350 g at time of OBX or Sham surgery[2]. Dosage: 20 mg/kg. Administration: I.P. daily for 17days. Result: Increased extracellular concentrations of dopamine, norepinephrine and serotonin in the medial prefrontal cortex of both OBX and Sham animals and significantly increased extracellular baseline serotonin concentrations. Animal Model: Male Sprague Dawley rats weighing between 290 and 350 g at time of OBX or Sham surgery[2]. Dosage: 20 mg/kg. Administration: I.P. once. Result: Significant increases in dopamine, norepinephrine and serotonin levels were measured in both OBX and Sham animals. |
| References |
| Molecular Formula | C11H11Cl2N |
|---|---|
| Molecular Weight | 228.12 |
| Exact Mass | 227.02700 |
| PSA | 12.03000 |
| LogP | 3.18310 |
| Storage condition | 2-8℃ |
| Precursor 5 | |
|---|---|
| DownStream 0 | |