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189209-27-6

189209-27-6 structure
189209-27-6 structure
  • Name: PROTAC Linker 17
  • Chemical Name: tert-butyl N-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethyl]carbamate
  • CAS Number: 189209-27-6
  • Molecular Formula: C17H36N2O7
  • Molecular Weight: 380.47700
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2017-04-29 08:08:23
  • Modify Date: 2024-01-15 11:56:35
  • PROTAC Linker 17 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 17 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Name tert-butyl N-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethyl]carbamate
Synonyms 19-Amino-5,8,11,14,17-pentaoxa-2-azanonadecanoic Acid 1,1-Dimethylethyl Ester
Boc-NH-PEG5-CH2CH2NH2
t-boc-N-amido-PEG5-Amine
Description PROTAC Linker 17 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 17 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Related Catalog
Target

Alkyl/ether

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Molecular Formula C17H36N2O7
Molecular Weight 380.47700
Exact Mass 380.25200
PSA 113.99000
LogP 1.45750
Hazard Codes Xi