Top Suppliers:I want be here



1173022-21-3

1173022-21-3 structure
1173022-21-3 structure
  • Name: STO-609 (acetate)
  • Chemical Name: 7H-​Benzimidazo[2,​1-​a]​benz[de]​isoquinoline-​3-​carboxylic acid, 7-​oxo-​, acetate (1:1)
  • CAS Number: 1173022-21-3
  • Molecular Formula: C21H14N2O5
  • Molecular Weight: 374.35
  • Catalog: Signaling Pathways Autophagy Autophagy
  • Create Date: 2018-06-13 06:48:28
  • Modify Date: 2024-01-06 10:58:20
  • STO-609 acetate is a selective and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK), with Ki values of 80 and 15 ng/mL for recombinant CaM-KKα and CaM-KKβ, respectively. STO-609 acetate inhibits AMP-activated protein kinase kinase (AMPKK) activity in HeLa cell lysates with an IC50 ~0.02 g/ml.

Name 7H-​Benzimidazo[2,​1-​a]​benz[de]​isoquinoline-​3-​carboxylic acid, 7-​oxo-​, acetate (1:1)
Synonyms 7-Oxo-7H-benzimidazo[2,1-a]benzo[de]isoquinoline-3-carboxylic acid acetate (1:1)
7H-Benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid, 7-oxo-, acetate (1:1)
Description STO-609 acetate is a selective and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK), with Ki values of 80 and 15 ng/mL for recombinant CaM-KKα and CaM-KKβ, respectively. STO-609 acetate inhibits AMP-activated protein kinase kinase (AMPKK) activity in HeLa cell lysates with an IC50 ~0.02 g/ml.
Related Catalog
References

[1]. Tokumitsu H, et al. STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase. J Biol Chem. 2002 May 3;277(18):15813-8.  

[2]. Kukimoto-Niino M, et al. Crystal structure of the Ca2+/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609. J Biol Chem. 2011 Jun 24;286(25):22570-9.  

Molecular Formula C21H14N2O5
Molecular Weight 374.35
Exact Mass 374.090271
PSA 108.97000
LogP 3.38100