51481-65-3

51481-65-3 structure

Name: Mezlocillin
Chemical Name: mezlocillin
CAS Number: 51481-65-3
Molecular Formula: C₂₁H₂₅N₅O₈S₂
Molecular Weight: 539.582
Catalog: API Antibiotics Penicillin
Create Date: 2018-09-10 15:50:19
Modify Date: 2024-01-08 13:10:29
Mezlocillin (BAY-f 1353) is a β-lactam antibiotic, a semisynthetic and extended-spectrum antibiotic. Mezlocillin is active against both gram-negative and gram-positive bacteria. Mezlocillin can be used in bacterial infection research[1][2].

Name	mezlocillin
Synonyms	6R-[2-[3-(Methylsulfonyl)-2-oxo-1-imidazolidine Carboxamido]-2-phenylacetamido]penicillanic Acid EINECS 257-233-8 (2S,5R,6R)-3,3-Dimethyl-6-{[(2R)-2-({[3-(methylsulfonyl)-2-oxoimidazolidin-1-yl]carbonyl}amino)-2-phenylacetyl]amino}-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid [2S-[2a,5a,6b(S*)]]-3,3-Dimethyl-6-[[[[[3-(methylsulfonyl)-2-oxo-1-imidazolidinyl]carbonyl]amino]phenylacetyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-6-[[(2R)-2-[[[3-(methylsulfonyl)-2-oxo-1-imidazolidinyl]carbonyl]amino]-2-phenylacetyl]amino]-7-oxo-, (2S,5R,6R)- (2S,5R,6R)-3,3-Dimethyl-6-((R)-2-(3-(methylsulfonyl)-2-oxo-1-imidazolidinecarboxamido)-2-phenylacetamido)-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid Antibiotic bay-f 1353 Mezlocillin Meloxacam acid MFCD00056866 Melocillin sodium antibioticbay-f1353 Multocillin Bay f 1353 (2S,5R,6R)-3,3-Dimethyl-6-{[(2R)-2-({[3-(methylsulfonyl)-2-oxo-1-imidazolidinyl]carbonyl}amino)-2-phenylacetyl]amino}-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid (2S,5R,6R)-3,3-Dimethyl-6-((R)-2-(3-(methylsulfonyl)-2-oxo-1-imidazolidinecarboxamido)-2-phenylacetamido)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid

Description	Mezlocillin (BAY-f 1353) is a β-lactam antibiotic, a semisynthetic and extended-spectrum antibiotic. Mezlocillin is active against both gram-negative and gram-positive bacteria. Mezlocillin can be used in bacterial infection research[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vivo	Mezlocillin (subcutaneous injection; 1.7-5.7 mg/kg; twice daily; 7 d) treatment in vivo suppresses the IgM and IgG responses and the delayed-type hypersensitivity reaction, observes the loss of hair, and inhibits lymphocyte proliferation of animals treated with all doses[1]. Animal Model: Male Balb/c mice[1] Dosage: 1.7, 4.3, and 5.7 mg/kg Administration: Subcutaneous injection; 1.7, 4.3, and 5.7 mg/kg; twice daily; 7 days Result: Suppressed the IgM and IgG responses and the delayed-type hypersensitivity reaction treated with all doses. Observed a loss of hair in the majority of animals treated with all doses. Inhibited lymphocyte proliferation of spleen-cell cultures from animals.

69-53-4

41762-76-9

~90%

51481-65-3

Literature: Koenig, H.-B.; Metzger, K. G.; Offe, H.-A.; Schroeck, W. Arzneimittel Forschung, 1983 , vol. 33, # 1 p. 88 - 90

Precursor 2
69-53-4 41762-76-9
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