60786-59-6

60786-59-6 structure

Name: (Thr4,Gly7)-Oxytocin
Chemical Name: G Oxytocin
CAS Number: 60786-59-6
Molecular Formula: C₃₉H₆₁N₁₁O₁₂S₂
Molecular Weight: 940.09800
Catalog: Signaling Pathways GPCR/G Protein Oxytocin Receptor
Create Date: 2019-01-01 00:42:27
Modify Date: 2024-01-10 11:52:33
(Thr4,Gly7)-Oxytocin, an Oxytocin analogue, is a specific OT receptor agonist. (Thr4,Gly7)-Oxytocin also excites subicular neurons via activation of TRPV1 channels, and depression of K+ channels. [1][2].

Name	G Oxytocin
Synonyms	3,3-DiallylthiacarbocyanineBromide CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2 [THR4,GLY7] OT H-CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2,(DISULFIDE BOND) Cys-Tyr-Ile-Thr-Asn-Cys-Gly-Leu-Gly-NH2 (Disulfide bridge Cys1-Cys6) TGOT H-CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2 thr(4)-gly(7)-oxytoci [THR4,GLY7]-OXYTOCIN

Description	(Thr4,Gly7)-Oxytocin, an Oxytocin analogue, is a specific OT receptor agonist. (Thr4,Gly7)-Oxytocin also excites subicular neurons via activation of TRPV1 channels, and depression of K+ channels. [1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Oxytocin Receptor Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	OT receptors, K+ channels[1].
In Vitro	(Thr4,Gly7)-Oxytocin (1 μM, 1 min) evokes an inward current of 5.9 pA in paraventricular thalamus (PVT) neurons[1]. (Thr4,Gly7)-Oxytocin (1 μM, 1 min) increases spontaneous excitatory postsynaptic currents (sEPSCs) frequency in PVT neurons[1]. (Thr4,Gly7)-Oxytocin (0.3 μM, 5 min) induces depolarization in both bursting cells and regular firing cells[2]. (Thr4,Gly7)-Oxytocin (0.3 μM, 5 min) depolarizes subicular neurons by activating TRPV1 channels[2].
In Vivo	(Thr4,Gly7)-Oxytocin (1 μM, direct intra-PVT infusion for 1 min) evokes depolarization on TGOT-responsive neurons in mice[1]. (Thr4,Gly7)-Oxytocin (100 ng, intracerebroventrical injection) increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats[3]. Animal Model: Swiss Webster mice [1] Dosage: 1 μM Administration: Intratracheal administration for 24 h Result: Excited 34.3% of aPVT neurons, 57.6% of mPVT neurons, and 60.0% of pPVT neurons. Increased the firing rate of TGOT-responsive PVT neurons in all subregions.
References	[1]. Lily R Barrett, et al. Oxytocin activation of paraventricular thalamic neurons promotes feeding motivation to attenuate stress-induced hypophagia. Neuropsychopharmacology. 2021 Apr;46(5):1045-1056. [2]. Binqi Hu, et al. Activation of Oxytocin Receptors Excites Subicular Neurons by Multiple Signaling and Ionic Mechanisms. Cereb Cortex. 2021 Mar 31;31(5):2402-2415. [3]. M R Melis, et al. Oxytocin increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats: correlation with penile erection and yawning. Regul Pept. 1997 Mar 26;69(2):105-11.

Density	1.332g/cm3
Molecular Formula	C₃₉H₆₁N₁₁O₁₂S₂
Molecular Weight	940.09800
Exact Mass	939.39400
PSA	436.06000
LogP	0.54950
Index of Refraction	1.587

Hazard Codes	Xn
Risk Phrases	20
Safety Phrases	36/37/39-45

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