65813-55-0

65813-55-0 structure

Name: 1-Oxo Ibuprofen
Chemical Name: 1-Oxo Ibuprofen
CAS Number: 65813-55-0
Molecular Formula: C₁₃H₁₆O₃
Molecular Weight: 220.26400
Catalog: analytical chemistry Analytical reagent Ion chromatography reagent
Create Date: 2018-12-27 12:27:30
Modify Date: 2024-01-05 18:56:17
1-Oxo Ibuprofen (Ibuprofen EP impurity J) is a degradation product and a potential impurity in preparations of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively[1][2].

Name	1-Oxo Ibuprofen
Synonyms	2-[4-(2-methylpropanoyl)phenyl]propanoic acid

Description	1-Oxo Ibuprofen (Ibuprofen EP impurity J) is a degradation product and a potential impurity in preparations of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. YongFang Rao, et al. Degradation of ibuprofen by a synergistic UV/Fe(III)/Oxone process. Chemical Engineering Journal. Volume 283, 1 January 2016, Pages 65-75. [2]. Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61(1):2-7.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Hazard Codes	Xn
Risk Phrases	22
RIDADR	NONH for all modes of transport
HS Code	2918300090

15687-27-1

38861-78-8

65813-55-0

Literature: Journal of the American Chemical Society, , vol. 130, # 5 p. 1628 - 1637

15687-27-1

65813-55-0

Literature: US6359182 B1, ; Page column 53 ;

15687-27-1

~1%

40150-98-9

38861-78-8

43153-07-7

Detail

Literature: Journal of the Chemical Society, Chemical Communications, , # 8 p. 601 - 602

Precursor 1
15687-27-1
DownStream 0

HS Code	2918300090
Summary	2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%