101622-51-9

101622-51-9 structure

Name: Olomoucine
Chemical Name: 2-[[6-(benzylamino)-9-methylpurin-2-yl]amino]ethanol
CAS Number: 101622-51-9
Molecular Formula: C₁₅H₁₈N₆O
Molecular Weight: 298.343
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2018-12-26 09:41:29
Modify Date: 2024-01-02 12:54:28
Olomoucine is an ATP competitive inhibitor of CDKs. Olomoucine is a purine (HY-34431) derivative and inhibits CDC2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E (both IC50=7 µM), CDK/p35 kinase (IC50=3 µM) and ERK1/p44 MAP kinase (IC50=25 µM)[1][2].

Name	2-[[6-(benzylamino)-9-methylpurin-2-yl]amino]ethanol
Synonyms	OLO olomoucine 2-{[6-(Benzylamino)-9-methyl-9H-purin-2-yl]amino}ethanol Ethanol, 2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]- MFCD00189360 Olomoucine,high purity 2-(6-Benzylamino-9-methyl-9H-purin-2-ylamino)-ethanol Olomoucine

Description	Olomoucine is an ATP competitive inhibitor of CDKs. Olomoucine is a purine (HY-34431) derivative and inhibits CDC2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E (both IC50=7 µM), CDK/p35 kinase (IC50=3 µM) and ERK1/p44 MAP kinase (IC50=25 µM)[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	cdk2-cyclin A:7 μM (IC50) cdk2-cyclin E:7 μM (IC50)
References	[1]. Vesely, J., Havlicek, J., Strnad, M., et al. Inhibition of cyclin-dependent kinases by purine analogues. European Journal of Biochemistry 224, 771-786 (1994). [2]. 2.Abraham, R.T., Acquarone, M., Andersen, A., et al. Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. Biology of the Cell 83(2), 105-120 (1995).

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3

101622-53-1

141-43-5

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Literature: Hocart, Charles H.; Letham, David S.; Parker, Charles W. Phytochemistry (Elsevier), 1991 , vol. 30, # 8 p. 2477 - 2486

141-43-5

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Literature: Nugiel; Cornelius; Corbett Journal of Organic Chemistry, 1997 , vol. 62, # 1 p. 201 - 203

5502-78-3

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Literature: Organic Letters, , vol. 8, # 11 p. 2425 - 2428

100-46-9

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Literature: Organic Letters, , vol. 8, # 11 p. 2425 - 2428

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Literature: Organic Letters, , vol. 8, # 11 p. 2425 - 2428

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Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 21 p. 2697 - 2702

5451-40-1

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Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 21 p. 2697 - 2702

67-56-1

141-43-5

1651-29-2

~66%

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Literature: Dorff, Peter H.; Garigipati, Ravi S. Tetrahedron Letters, 2001 , vol. 42, # 15 p. 2771 - 2773

2382-10-7

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Literature: Phytochemistry (Elsevier), , vol. 25, # 2 p. 303 - 310